We are focused on two main areas of investigation relating to translational oncology. In the first area, we are delineating the mechanisms by which tumor cells adapt to both cell-intrinsic stress (e.g., oncogene dysregulation) and cell-extrinsic stress (e.g., nutrient limitation and hypoxia), with an emphasis on the Integrated Stress Response (ISR). We are identifying key nodes of ISR signalling and we then develop molecular approaches to target these nodes to delay tumor growth and metastasis and improve survival. The second area of interest entails the development of novel, more physiologically relevant animal models of incidental radiation damage and employing novel radiaiton delivery technologies (such as FLASH RT) in order to develop biomarkers of response to RT and to improve the therapeutic window of RT.